GA-Rodents: Colony Management, breeding strategies and genetic quality control

Fondazione Guido Bernardini is happy to collaborate in the realization of this course, The Francis Crick Institute designed and delivered by the Francis Crick Institute Colony Management Platform. 

The training will cover the best practice elements of running a Colony Management (CM) programme, from sourcing and validating your mouse models (via genotyping, genetic monitoring, phenotyping), to optimal management and performance of the lines, as well as breeding cohorts, archiving and rederivation strategies.

The aim of this course is to provide an overview of the aspects that should be considered to ensure mouse lines are characterised thoroughly and can be managed as efficiently as possible for scientific best practice and providing stakeholder value. We will cover the theoretical principles of colony management, and attendees will have the opportunity to analyse and discuss case studies and ask questions to a panel of subject matter experts, in order to acquire essential skills and knowledge to apply in their daily practice relevant to their own institute.

Attendees will have the opportunity to submit samples from their own facilities to Transnetyx for a facility specific genome analysis.  Included within the course costs, all attendees will be provided shipment materials and relevant submission processes so they can send samples from mice within their facilities to analyse their genome using the miniMUGA panel. We will then spend a practical session performing live analysis of your samples to give attendees personally applicable analysis to accompany our own examples.

The course will be run by the Colony Management team from Francis Crick Institute Biological Research Facility (BRF), aiming to provide a discreet, flexible and comprehensive package of support that enables the efficient and effective mouse management of colonies at the Crick. An emphasis on optimising breeding efficiency is placed with a focus on genetic integrity and reducing breeding surplus. We also provide GA breeding support and training to Crick’s scientists. Ensuring reliable and reproducible research and best practice in animal welfare is at the heart of what we do.

The course is sponsored by Transnetyx

From:

19/09/2024

To:

20/09/2024

Language: English
Teaching method:

In person course 
Location:

London

Duration: 2 days
CPD Credits:

This training is approved by the Royal Society of Biology. Training course approval is an independent review process that recognises relevant, high quality training. Upon completion of this course, attendees can claim 48 CPD points. 

 

The two-day course has been awarded 25 IAT CPD points for attendance.
Target audience:

This course is aimed at laboratory animal professionals running or involved in the management of a large number of rodent colonies, such as colony managers and coordinators, senior animal technicians, and facility managers. 
Learning outcomes:

By the end of the training, attendees will be able to:

 

  • Understand the key factors required for optimal colony management (CM);
  • Understand and apply useful tips and tools to assist with implementation of optimal colony management; 
  • Understand and apply the organisational management structures and services necessary for optimal CM;
  • Understand quality assurance and maintenance processes of inbred & GA strains, and evaluate their own set up to implement relevant pipelines; 
  • Evaluate data analysis for GA Colonies, with particular reference to genetic background and microbiome.

 
Contents:
  • Importance of Colony Management for Quality Control and Genetic Integrity
  • Choosing strains - finding the right mutation, tools & resources.
  • Overview on validating models
  • Breeding Strategies for Maintaining Colonies of Laboratory Mice
  • GM Data examples and analysis
  • Colony Sizing Scenarios
  • Cryopreservation
  • Genetic Monitoring: Importance of Genetic background & stability
  • Colony Management Reporting and analysis tools
  • Microbiota - monitoring of stability and impact on phenotype

 

 
Number of participants:

Maximum 20 participants 
Selection of the participants:

CVs will be reviewed by the Course Committee to ensure that the applicants have the same professional scope in order to share common background and to maximize the training experience.

 

Please send your CV to secretary@fondazioneguidobernardini.org  by the 5th of April to apply for a place. 
Registration fee:

580 Euro + 22% VAT RATE when applicable

Imperial College London, University College London (UCL) and King’s College London (10 seats): 465 Euro + 22% VAT RATE when applicable
Flyer: Here the programme

 



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